Endocrine Abstracts

Addisons disease is a rare but potentially life threatening endocrine disorder. It is well-known for disguising as a variety of presentations before diagnosis. Here we present a case report of Addison’s disease presenting with very severe hyponatraemia. A 35 year old lady was admitted with lethargy, low mood, weight loss and feeling generally unwell for the last 3 months. Six weeks prior to her admission, her GP arranged some routine investigations including U&E which...

The Case: We are presenting a 51-year-old Caucasian lady with known type 1 diabetes who was diagnosed with Autoimmune Addison’s Disease (AAD) during investigation of persistent hyponatremia. She was admitted with DKA back in November 2022 that was believed to be due to gastroenteritis. Usually, her diabetes control has been reasonable over the years with no severe chronic complications or diabetes-related hospital admissions. In the hospital, she suffered from ongoing hyp...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Severe Hypercalcaemia can present as a life threatening emergency requiring urgent measures to lower the calcium. Usually, this is associated with Primary Hyperparathyroidism. It can result in obtundation, oliguria, anuria, collapse or arrhythmias. It is important to act fast and decisively to prevent fatal complications.We describe a 39 year old gentleman who was a tennis coach, who was brought after he collapsed in his bathroom. ...

The milk – alkali syndrome was well known in the pre-proton pump inhibitor era when remedies for peptic ulcer included a large amount of calcium and sodium bicarbonate resulting in hypercalcaemia, metabolic alkalosis and often acute kidney injury. In a study done from 1998 to 2003, milk alkali syndrome was the cause of hypercalcaemia in 8.8 percent of the cases which is a significant percentage, so awareness about it is important.<p class="abste...

Severe Hypercalcaemia can present as a life threatening emergency requiring urgent measures to lower the calcium. Usually, this is associated with Primary Hyperparathyroidism. It can result in obtundation, oliguria, anuria, collapse or arrhythmias. It is important to act fast and decisively to prevent fatal complications.We describe a 39 year old gentleman who was a tennis coach, who was brought after he collapsed in his bathroom. ...

Hyponatremia is the commonest electrolyte abnormality presenting to Medical Admissions and when acute, severe and symptomatic, is associated with high mortality. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common underlying disorder in hospitalised patients with euvolaemic hyponatraemia and is a complication of many clinical conditions and drug therapies.We discuss the cases of two patients...

Hyponatremia is the commonest electrolyte abnormality presenting to Medical Admissions and when acute, severe and symptomatic, is associated with high mortality. The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is the most common underlying disorder in hospitalised patients with euvolaemic hyponatraemia and is a complication of many clinical conditions and drug therapies.We discuss the cases of two patients...

Ectopic Cushing’s syndrome (CS) is commonly caused by malignancy, often behaves aggressively and may not clinically manifest with features of hypercortisolism due to its rapid course and associated cachexia. This may mislead clinicians into discounting the diagnosis in patients with more indolent features of CS. We present a 41 year old woman with an 8 year history of Cushingoid features with associated hypertension, obesity and Type 2 Diabetes. Investigations confirmed C...